N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine
FMOC-beta-Alanine
CAS: 35737-10-1
Molecular Formula: C18H17NO4
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine - Names and Identifiers
| Name | FMOC-beta-Alanine |
| Synonyms | FMOC-b-Ala-OH Fmoc-β-Ala-OH Fmoc-b-alanine FMOC-beta-Alanine FMOC-BETA-ALANINE FMOC-GLY(C*CH2)-OH FMOC-L-BETA-ALA-OH FMOC-NH-(CH2)2-COOH FMOC--ALA-OH Novabiochem 3-Fmoc-aminopropanoic acid N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-beta-alanine 3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate |
| CAS | 35737-10-1 |
| InChI | InChI=1/C18H17NO4/c20-17(21)9-10-19-18(22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,22)(H,20,21)/p-1 |
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine - Physico-chemical Properties
| Molecular Formula | C18H17NO4 |
| Molar Mass | 311.34 |
| Density | 1.2626 (rough estimate) |
| Melting Point | 142-147°C |
| Boling Point | 451.38°C (rough estimate) |
| Flash Point | 290°C |
| Water Solubility | Soluble in water and 1% acetic acid. |
| Vapor Presure | 3.43E-13mmHg at 25°C |
| Appearance | White powder |
| BRN | 2302327 |
| pKa | 4.41±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5100 (estimate) |
| MDL | MFCD00063328 |
| Use | An Fmoc protected alanine derivative |
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine - Reference Information
| application | FMOC-beta-alanine is an amino acid derivative widely used in the synthesis of drugs and peptides. |
| preparation method | β-alanine (β-Ala)(0.5g,6.61mmol) was dissolved in 10% NaCO3(12ml) under stirring in a 50ml flask. Gradually add Fmoc-Cl(1.45g,5.61mmol) of dioxane (10ml) solution to the resulting solution that has been placed in an ice bath. The reaction mixture was stirred at room temperature for 4 hours, then water (80ml) was added. The effluent phase layer was separated from the reaction mixture and stripping with ether three times (75ml × 3). The stripping water layer was acidified with an aqueous solution of 2NHCl to a pH of 2, and then extracted with ethyl acetate three times (75ml × 3). The organic phase layer was recovered and concentrated to obtain 1.50g of crude product. The crude product was recrystallized in a mixed solvent (30ml) of ethyl acetate: hexane = 1 ∶ 2, and filtered under reduced pressure to obtain a white solid, expressed as FMOC-beta-alanine. |
Last Update：2024-04-09 20:52:54
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